fIVE DB

from In Vitro Experiments DataBase

fIVE DB  is an InSysBio project for in vitro experiments information collection and processing.

fIVE DB is designed for Quantitative Systems Pharmacology (QSP) modelers and scientists who deal with in vitro/ex vivo data analysis to simplify their hard work and avoid potential errors.

Information collected in the database enables them to save time typically spent for gathering and processing of literature and available data utilized for:

• comparative analysis of in vitro/ex vivo experimental data describing kinetics and regulations of a cell mediated processes (secretion, proliferation, differentiation, migration etc) collected from publicly available sources
• comparative analysis of mean values and ranges of the parameters describing kinetics and regulations of cell mediated processes calculated on the basis of the data measured in patients suffering from different diseases
• facilitation of parameters identification for development and calibration of QSP models based on in vitro data including:
  • calibration of a QSP model of a reference virtual patient (VP) against mean values of the parameters
  • implementation of variability in a QSP model basing on the ranges of parameters and selection of plausible VP population

fIVE DB  contains the quantitative data on human cells or cell lines obtained in vitro and ex vivo. The data describes major cell processes such as proliferation, cell death, differentiation, activation, secretion, and others. The data is collected from the public domain sources, processed, and stored in fIVE DB as content.

Data processing includes the calculation of parameters suitable for cell process description via mathematical models. The parameters calculation is based on InSysBio way of regulators impact implementation in the models and pre-derived equations describing typical in vitro experiments. To learn more, please visit InSysBio's Blog and Immune Response Template.