fIVE DB - from In Vitro Experiments DataBase

fIVE DB  is an InSysBio UK Ltd project for in vitro experiments information collection and processing.

fIVE DB is designed for Quantitative Systems Pharmacology (QSP) modelers and scientists who work with in vitro/ex vivo data, helping them simplify their workflows and avoid potential errors.

Information collected in the database enables them to save time typically spent on gathering and processing literature and available data utilized for:

• comparative analysis of in vitro/ex vivo experimental data describing kinetics and regulation of cell-mediated processes (secretion, proliferation, differentiation, migration, etc.) collected from publicly available sources
• comparative analysis of mean values and ranges of the parameters describing kinetics and regulation of cell-mediated processes calculated on the basis of the data measured in patients suffering from different diseases
• facilitation of parameter identification for development and calibration of QSP models based on in vitro data, including:
  • calibration of a QSP model of a reference virtual patient (VP) against mean values of the parameters
  • implementation of variability in a QSP model based on the ranges of parameters and selection of a plausible VP population.

fIVE DB  contains the quantitative data on human cells or cell lines obtained in vitro and ex vivo. The data describe major cell processes such as proliferation, cell death, differentiation, activation, secretion, and others. The data are collected from public domain sources, processed, and stored in fIVE DB as content.

Data processing includes the calculation of parameters suitable for cell process description via mathematical models. The calculation of parameters is based on the InSysBio approach to implementing regulator effects in the models and pre-derived equations describing typical in vitro experiments. To learn more, please visit InSysBio's Blog and Immune Response Template.